Progression of falls in postmortem‐confirmed Parkinsonian disorders
Identifieur interne : 000541 ( France/Analysis ); précédent : 000540; suivant : 000542Progression of falls in postmortem‐confirmed Parkinsonian disorders
Auteurs : Gregor K. Wenning [Autriche] ; Georg Ebersbach [Autriche] ; Marc Verny [France] ; K. Ray Chaudhuri [Royaume-Uni] ; Kurt Jellinger [Autriche] ; Ann Mckee [États-Unis] ; Werner Poewe [États-Unis] ; Irene Litvan [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1999-11.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Accidental Falls (statistics & numerical data), Adult, Aged, Aged, 80 and over, Atypical parkinsonism, Brain (pathology), Comparative study, Disease Progression, Evolution, Fall, Falls, Female, Gait, Gait disorder, Gait disturbance, Human, Humans, Lewy Body Disease (mortality), Lewy Body Disease (pathology), Male, Middle Aged, Multiple System Atrophy (mortality), Multiple System Atrophy (pathology), Neurologic Examination, Parkinson Disease (mortality), Parkinson Disease (pathology), Parkinson disease, Parkinson's disease, Parkinsonian Disorders (mortality), Parkinsonian Disorders (pathology), Progressive, Progressive supranuclear palsy, Recurrence, Recurrent, Supranuclear Palsy, Progressive (mortality), Supranuclear Palsy, Progressive (pathology), Supranuclear ophthalmoplegia.
- MESH :
- mortality : Lewy Body Disease, Multiple System Atrophy, Parkinson Disease, Parkinsonian Disorders, Supranuclear Palsy, Progressive.
- pathology : Brain, Lewy Body Disease, Multiple System Atrophy, Parkinson Disease, Parkinsonian Disorders, Supranuclear Palsy, Progressive.
- statistics & numerical data : Accidental Falls.
- Adult, Aged, Aged, 80 and over, Disease Progression, Female, Gait, Humans, Male, Middle Aged, Neurologic Examination, Recurrence.
Abstract
Although falls are known to occur in several parkinsonian disorders, such as Parkinson's disease (PD), multiple system atrophy (MSA), dementia with Lewy bodies (DLB), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP), differences in the evolution of this feature have not been studied systematically in pathologically confirmed cases. Seventy‐seven cases with pathologically confirmed parkinsonian disorders (PD: n = 11, MSA: n = 15, DLB: n = 14, CBD: n = 13, PSP: n = 24), collected up to 1994, formed the basis for a multicenter clinicopathologic study organized by the National Institute of Neurological Disorders and Stroke to improve differential diagnosis of parkinsonian disorders. In the present study, we determined the time course, that is, the duration from first symptom to onset (latency) and duration from onset to death, of recurrent falls. Furthermore, we analyzed the diagnostic validity of a predefined latency to onset of recurrent falls within 1 year of symptom onset. Significant group differences for latency, but not duration, of recurrent falls were observed. Latencies to onset of falls were short in PSP patients, intermediate in MSA, DLB, and CBD, and long in PD. Recurrent falls occurring within the first year after disease onset predicted PSP in 68% of the patients. Our study demonstrates for the first time that latency to onset, but not duration, of recurrent falls differentiates PD from other parkinsonian disorders. Whereas early falls are important for the diagnosis of PSP, the addition of other features increases its diagnostic predictive value.
Url:
DOI: 10.1002/1531-8257(199911)14:6<947::AID-MDS1006>3.0.CO;2-O
Affiliations:
- Autriche, France, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Maryland, Massachusetts, Tyrol (Land), Vienne (Autriche)
- Innsbruck, Londres, Paris, Vienne (Autriche)
- Université de médecine d'Innsbruck
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ISTEX:9812F05A7AD240ABF51FFE19E8CD93E4BC5910BELe document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="1999-11">1999-11</date><biblScope unit="vol">14</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="947">947</biblScope><biblScope unit="page" to="950">950</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">9812F05A7AD240ABF51FFE19E8CD93E4BC5910BE</idno><idno type="DOI">10.1002/1531-8257(199911)14:6<947::AID-MDS1006>3.0.CO;2-O</idno><idno type="ArticleID">MDS1006</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Accidental Falls (statistics & numerical data)</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Atypical parkinsonism</term><term>Brain (pathology)</term><term>Comparative study</term><term>Disease Progression</term><term>Evolution</term><term>Fall</term><term>Falls</term><term>Female</term><term>Gait</term><term>Gait disorder</term><term>Gait disturbance</term><term>Human</term><term>Humans</term><term>Lewy Body Disease (mortality)</term><term>Lewy Body Disease (pathology)</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (mortality)</term><term>Multiple System Atrophy (pathology)</term><term>Neurologic Examination</term><term>Parkinson Disease (mortality)</term><term>Parkinson Disease (pathology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Parkinsonian Disorders (mortality)</term><term>Parkinsonian Disorders (pathology)</term><term>Progressive</term><term>Progressive supranuclear palsy</term><term>Recurrence</term><term>Recurrent</term><term>Supranuclear Palsy, Progressive (mortality)</term><term>Supranuclear Palsy, Progressive (pathology)</term><term>Supranuclear ophthalmoplegia</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Lewy Body Disease</term><term>Multiple System Atrophy</term><term>Parkinson Disease</term><term>Parkinsonian Disorders</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Lewy Body Disease</term><term>Multiple System Atrophy</term><term>Parkinson Disease</term><term>Parkinsonian Disorders</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Accidental Falls</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease Progression</term><term>Female</term><term>Gait</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Recurrence</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chute</term><term>Etude comparative</term><term>Evolution</term><term>Homme</term><term>Ophtalmoplégie supranucléaire</term><term>Parkinson maladie</term><term>Progressif</term><term>Récidivant</term><term>Trouble marche</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although falls are known to occur in several parkinsonian disorders, such as Parkinson's disease (PD), multiple system atrophy (MSA), dementia with Lewy bodies (DLB), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP), differences in the evolution of this feature have not been studied systematically in pathologically confirmed cases. Seventy‐seven cases with pathologically confirmed parkinsonian disorders (PD: n = 11, MSA: n = 15, DLB: n = 14, CBD: n = 13, PSP: n = 24), collected up to 1994, formed the basis for a multicenter clinicopathologic study organized by the National Institute of Neurological Disorders and Stroke to improve differential diagnosis of parkinsonian disorders. In the present study, we determined the time course, that is, the duration from first symptom to onset (latency) and duration from onset to death, of recurrent falls. Furthermore, we analyzed the diagnostic validity of a predefined latency to onset of recurrent falls within 1 year of symptom onset. Significant group differences for latency, but not duration, of recurrent falls were observed. Latencies to onset of falls were short in PSP patients, intermediate in MSA, DLB, and CBD, and long in PD. Recurrent falls occurring within the first year after disease onset predicted PSP in 68% of the patients. Our study demonstrates for the first time that latency to onset, but not duration, of recurrent falls differentiates PD from other parkinsonian disorders. Whereas early falls are important for the diagnosis of PSP, the addition of other features increases its diagnostic predictive value.</div></front></TEI><affiliations><list><country><li>Autriche</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Maryland</li><li>Massachusetts</li><li>Tyrol (Land)</li><li>Vienne (Autriche)</li></region><settlement><li>Innsbruck</li><li>Londres</li><li>Paris</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Autriche"><noRegion><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name></noRegion><name sortKey="Ebersbach, Georg" sort="Ebersbach, Georg" uniqKey="Ebersbach G" first="Georg" last="Ebersbach">Georg Ebersbach</name><name sortKey="Jellinger, Kurt" sort="Jellinger, Kurt" uniqKey="Jellinger K" first="Kurt" last="Jellinger">Kurt Jellinger</name></country><country name="France"><noRegion><name sortKey="Verny, Marc" sort="Verny, Marc" uniqKey="Verny M" first="Marc" last="Verny">Marc Verny</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Chaudhuri, K Ray" sort="Chaudhuri, K Ray" uniqKey="Chaudhuri K" first="K. Ray" last="Chaudhuri">K. Ray Chaudhuri</name></region></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Mckee, Ann" sort="Mckee, Ann" uniqKey="Mckee A" first="Ann" last="Mckee">Ann Mckee</name></region><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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